Yanli Y, Eren A
Department of Anaesthesia, Ordu National Hospital, Turkey.
Anaesthesia. 1996 Jan;51(1):84-6. doi: 10.1111/j.1365-2044.1996.tb07662.x.
In a randomised, double blind study of 30 patients, we have compared two regimens for extradural anaesthesia: 20 ml bupivacaine 0.5%, 25 mg (0.5 ml) ketamine, 1 in 200,000 adrenaline; and 20 ml bupivacaine 0.5%, 0.5 ml 0.9% saline, 1 in 200,000 adrenaline. The main outcome measures were onset time to acceptable bilateral anaesthesia and postoperative analgesic duration. The time to onset of anaesthesia was reduced by 8 min in the bupivacaine-ketamine group compared with the bupivacaine alone group. In addition, the anaesthetic levels were two segments higher in the bupivacaine-ketamine group (T7 versus T9). Side effects were similar in both groups and there was no significant difference in postoperative analgesic requirements between the two groups. The addition of ketamine to bupivacaine given epidurally appears to be useful in the reduction of onset time to blockade.
在一项针对30例患者的随机双盲研究中，我们比较了两种硬膜外麻醉方案：20毫升0.5%布比卡因、25毫克（0.5毫升）氯胺酮、1:200000肾上腺素；以及20毫升0.5%布比卡因、0.5毫升0.9%生理盐水、1:200000肾上腺素。主要观察指标为达到可接受双侧麻醉的起效时间和术后镇痛持续时间。与单纯布比卡因组相比，布比卡因-氯胺酮组的麻醉起效时间缩短了8分钟。此外，布比卡因-氯胺酮组的麻醉平面高两个节段（T7对T9）。两组的副作用相似，两组术后镇痛需求无显著差异。硬膜外给予布比卡因时添加氯胺酮似乎有助于缩短阻滞起效时间。
