Fujii Y, Tanaka H, Toyooka H
Department of Anaesthesiology, Toride Kyodo General Hospital, Ibaraki, Japan.
Anaesth Intensive Care. 1996 Feb;24(1):42-4. doi: 10.1177/0310057X9602400107.
We studied the effects of intraoperative use of air in oxygen (O2) (FiO2 = 0.33) versus nitrous oxide (N2O) in O2 (FiO2 = 0.33) on the degree of postoperative hypoxaemia in 30 patients undergoing laparoscopic cholecystectomy. Patients were randomly allocated to receive either general anaesthesia with air (Group A, n = 15) or with N2O (Group N, n = 15). Arterial gas tensions were measured before, 24 h and 48 h after surgery while breathing room air. The mean PaO2 24 h and 48 h postoperatively decreased significantly in both groups compared with the preoperative values. The mean PaO2 24 h postoperatively in Group N (74.6 +/- 6.4 mmHg) tended to be lower than that in Group A (78.1 +/- 8.3 mmHg). The mean PaO2 48 h postoperatively in Group N (75.0 +/- 7.8 mmHg) was significantly lower than that in Group A (83.5 +/- 7.9 mmHg) (P < 0.05). On the contrary, the mean PaCO2 did not show any significant change during 48 h postoperatively in either group. Our results suggest that ventilation with N2O and O2 during laparoscopic cholecystectomy is associated with a lower degree of postoperative hypoxaemia.
我们研究了在30例行腹腔镜胆囊切除术的患者中，术中使用氧气（O2）中混入空气（FiO2 = 0.33）与氧气（O2）中混入氧化亚氮（N2O）（FiO2 = 0.33）对术后低氧血症程度的影响。患者被随机分配接受空气全麻（A组，n = 15）或氧化亚氮全麻（N组，n = 15）。在术后24小时和48小时呼吸室内空气时测量动脉血气张力。与术前值相比，两组术后24小时和48小时的平均动脉血氧分压（PaO2）均显著降低。N组术后24小时的平均PaO2（74.6±6.4 mmHg）低于A组（78.1±8.3 mmHg）。N组术后48小时的平均PaO2（75.0±7.8 mmHg）显著低于A组（83.5±7.9 mmHg）（P < 0.05）。相反，两组术后48小时内平均动脉血二氧化碳分压（PaCO2）均未显示任何显著变化。我们的结果表明，腹腔镜胆囊切除术中使用氧化亚氮和氧气通气与较低程度的术后低氧血症有关。
