Charpin C, Bacquie N, Bouvier C, Devictor B, Boulat J, Andrac L, Lavaut M N, Allasia C, Piana L
Department of Pathology, Hôpital de la Timone, Marseille, France.
Anticancer Res. 1995 Nov-Dec;15(6B):2611-7.
Paraffin sections of 185 breast carcinomas were reexamined in order to compare the current SBR histoprognostic grade (SBR) with to modified methods of grading recently proposed by two groups, Le Doussal et al (MSBR) and Elston et al (SBR-Elston). In each tumor, the SBR, MSBR, SBR-Elston, and each of their components were correlated with recurrence, metastases and survival rates (follow up 7 to 96 months, m = 52, SD = 19) (Kaplan-Meier test). The Nottingham prognostic index (NPI) was computed for each patient, the histological type reevaluated and both were also correlated with the patient follow up. Our results show that the three methods of grading were significantly (p < 0.0001) correlated. The three grades, were significantly correlated with metastases and survival, but not with the recurrence rates. The differentiation, the nuclear pleomorphism and the mitoses count also correlated with the metastases rate and overall survival but the mitoses number appeared to be a stronger prognostic indicator. The MSBR grading made it possible to refine the prognostic of the tumors usually scored as SBR grade 2. The NPI significantly correlated with metastases and survival (p < 0.0001), whereas the histological types were found to have no prognostic significance.
对185例乳腺癌的石蜡切片进行重新检查，以便将当前的SBR组织预后分级（SBR）与最近由两组人提出的改良分级方法进行比较，即勒杜萨尔等人提出的方法（MSBR）和埃尔斯顿等人提出的方法（SBR - 埃尔斯顿）。在每例肿瘤中，将SBR、MSBR、SBR - 埃尔斯顿及其各自的组成部分与复发、转移和生存率进行相关性分析（随访7至96个月，m = 52，标准差 = 19）（Kaplan - Meier检验）。为每位患者计算诺丁汉预后指数（NPI），重新评估组织学类型，并且二者也与患者随访情况进行相关性分析。我们的结果表明，三种分级方法具有显著相关性（p < 0.0001）。这三个分级与转移和生存显著相关，但与复发率无关。分化程度、核异型性和有丝分裂计数也与转移率和总生存率相关，但有丝分裂数量似乎是更强的预后指标。MSBR分级使得对通常评为SBR 2级的肿瘤的预后评估得以细化。NPI与转移和生存显著相关（p < 0.0001），而组织学类型没有预后意义。
