Westermark P, Sletten K, Westermark G T, Raynes J, McAdam K P
Department of Pathology I, University Hospital, Linköping, Sweden.
Biochem Biophys Res Commun. 1996 Jun 14;223(2):320-3. doi: 10.1006/bbrc.1996.0892.
A major protein AA amyloid protein was purified and characterised from a Papua New Guinnean individual. This AA protein differed from all previously characterised SAA variants by the combination of Ala52, Val57, Asn60, Phe68, Phe69 and Gly72. Since the prevalence of AA-amyloidosis is unusually high in Papua New Guinea this AAdelta must originate from a novel SAAdelta which may represent a particularly amyloidogenic variant.
从一名巴布亚新几内亚人身上纯化并鉴定出一种主要的蛋白质AA淀粉样蛋白。这种AA蛋白与所有先前鉴定的SAA变体不同，它由Ala52、Val57、Asn60、Phe68、Phe69和Gly72组合而成。由于AA淀粉样变性在巴布亚新几内亚的患病率异常高，这种AAδ必定源自一种新型SAAδ，它可能代表一种特别具有淀粉样变性的变体。
