普萘洛尔对兔自发性再激活后眼部单纯疱疹病毒1型复发及相关角膜病变的抑制作用
Propranolol suppression of ocular HSV-1 recurrence and associated corneal lesions following spontaneous reactivation in the rabbit.
作者信息
Kaufman H E, Varnell E D, Gebhardt B M, Thompson H W, Hill J M
机构信息
The LSU Eye Center, Louisiana State University Medical Center School of Medicine, 2020 Gravier Street, Suite B, New Orleans, LA 70112-2234, USA.
出版信息
Curr Eye Res. 1996 Jun;15(6):680-4. doi: 10.3109/02713689609008909.
PURPOSE
Hyperthermia has been shown to induce HSV-1 ocular shedding in mice. Systemic administration of propranolol significantly reduced the recovery of infectious virus in the tears, cornea, and trigeminal ganglia of mice subjected to hyperthermia. The present study was performed to determine the effects of systemic propranolol on ocular shedding and recurrent corneal epithelial lesions in the rabbit model.
METHODS
New Zealand white rabbits were infected with HSV-1 strain McKrae or 17Syn+. After latency was established, the animals were treated with systemic propranolol or saline (control) and examined by slit lamp biomicroscopy for corneal lesion. Tear film swabs were cultured to determine the frequency and duration of viral shedding.
RESULTS
Propranolol caused a significant reduction in the frequency and duration of ocular HSV-1 shedding and a reduction in the frequency of recurrent corneal epithelia disease, compared with saline treatment.
CONCLUSIONS
These results suggest that beta-adrenergic receptor blockers such as propranolol could be useful in suppressing HSV-1 ocular recurrences and corneal disease.
目的
热疗已被证明可诱导小鼠眼部单纯疱疹病毒1型（HSV-1）脱落。对接受热疗的小鼠全身给予普萘洛尔可显著减少泪液、角膜和三叉神经节中感染性病毒的恢复。本研究旨在确定全身应用普萘洛尔对兔模型中眼部病毒脱落和复发性角膜上皮病变的影响。
方法
用HSV-1 McKrae株或17Syn +株感染新西兰白兔。潜伏期建立后，给动物全身应用普萘洛尔或生理盐水（对照），并用裂隙灯显微镜检查角膜病变情况。培养泪膜拭子以确定病毒脱落的频率和持续时间。
结果
与生理盐水治疗相比，普萘洛尔可显著降低眼部HSV-1脱落的频率和持续时间，并降低复发性角膜上皮疾病的频率。
结论
这些结果表明，β-肾上腺素能受体阻滞剂如普萘洛尔可能有助于抑制HSV-1眼部复发和角膜疾病。
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