Govaerts I, Koenig I, Van den Bergh M, Bertrand E, Revelard P, Englert Y
CUB Erasme, Department of Gynecology and Obstetrics, Brussels, Belgium.
Hum Reprod. 1996 Feb;11(2):440-3. doi: 10.1093/humrep/11.2.440.
The aim of this study was to evaluate the safety of the intracytoplasmic sperm injection (ICSI) procedure by analysing early pregnancy data from ICSI and in-vitro fertilization (IVF) patients. In all, 50 ICSI pregnancies were compared with 226 IVF pregnancies. Comparisons were made during the first 9 weeks after the theoretical last menstrual period (7 weeks after oocyte retrieval) with regard to epidemiological data, plasma hormonal concentrations and transvaginal ultrasonographical findings. Although patients were significantly (P < 0.001) younger in ICSI (31 years) than in IVF pregnancies (33 years), their duration of infertility was similar. Miscarriage and multiple gestation rates were not significantly different in ICSI pregnancies (respectively 24 and 24%) from those found after IVF (32 and 29%). The probability of developmental arrest of the intrauterine sac (miscarriages and vanishing twins) was similar in both ICSI (16%) and IVF (25%) cases. The mean plasma hormonal concentrations starting from day 11 after oocyte retrieval were similar in both groups. Every ICSI and IVF pregnancy showed an embryo with cardiac activity at 7 weeks. Early pregnancy data did not show any abnormal findings for pregnancies achieved using ICSI compared to those achieved by IVF.
本研究的目的是通过分析卵胞浆内单精子注射（ICSI）和体外受精（IVF）患者的早期妊娠数据，评估ICSI程序的安全性。总共将50例ICSI妊娠与226例IVF妊娠进行了比较。在理论上最后一次月经周期后的前9周（取卵后7周），就流行病学数据、血浆激素浓度和经阴道超声检查结果进行了比较。尽管ICSI组患者（31岁）比IVF妊娠患者（33岁）明显年轻（P<0.001），但他们的不孕持续时间相似。ICSI妊娠的流产率和多胎妊娠率（分别为24%和24%）与IVF后的流产率和多胎妊娠率（32%和29%）没有显著差异。子宫内囊发育停滞（流产和消失双胎）的概率在ICSI组（16%）和IVF组（25%）中相似。两组从取卵后第11天开始的平均血浆激素浓度相似。在7周时，每例ICSI和IVF妊娠均显示胚胎有心脏活动。与IVF获得的妊娠相比，ICSI获得的妊娠的早期妊娠数据未显示任何异常发现。
