Qasim S M, Trias A, Karacan M, Shelden R, Kemmann E
Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
Hum Reprod. 1996 May;11(5):1008-10. doi: 10.1093/oxfordjournals.humrep.a019285.
Sperm preparations for intrauterine insemination (IUI) generally do not include seminal fluid, and it is not known whether the absence of this component affects pregnancy rates. Therefore we evaluated the effect of high intravaginal seminal fluid deposition on clinical pregnancy rates in patients undergoing ovulation induction and IUI therapy. A prospective, randomized, double-blind study was designed for an infertile population in a university-based infertility practice. Patients were randomized to receive high vaginal deposition of either seminal fluid separated from the husband's ejaculate (study group) or normal saline solution (control group). Intercourse was restricted. A comparison of clinical pregnancy rates per cycle between study and control groups showed no significant difference between them [22/164 (13.4%) and 19/155 (12.3%) respectively]. Furthermore, in non-participants with unregulated intercourse, the pregnancy rate per cycle was not significantly different (40/307; 13.0%). Miscarriage rates between the study and control groups were similar. As high intravaginal deposition of seminal fluid at the time of IUI does not improve the clinical pregnancy rate in patients undergoing ovulation induction and IUI therapy, our study suggests that, after ejaculation, clinically significant biological contributions of seminal fluid to the achievement of pregnancy are bypassed by well-timed IUI.
宫内人工授精（IUI）的精子制剂通常不包括精液，目前尚不清楚缺少该成分是否会影响妊娠率。因此，我们评估了在接受排卵诱导和IUI治疗的患者中，高剂量阴道内精液沉积对临床妊娠率的影响。在一所大学附属医院的不孕不育门诊，针对不孕不育人群设计了一项前瞻性、随机、双盲研究。患者被随机分为两组，分别接受来自丈夫精液分离出的高剂量阴道内精液沉积（研究组）或生理盐水溶液（对照组）。限制性交。研究组和对照组每个周期的临床妊娠率比较显示，两组之间无显著差异[分别为22/164（13.4%）和19/155（12.3%）]。此外，在性交未受控制的未参与研究的患者中，每个周期的妊娠率也无显著差异（40/307；13.0%）。研究组和对照组的流产率相似。由于在IUI时高剂量阴道内精液沉积并不能提高接受排卵诱导和IUI治疗患者的临床妊娠率，我们的研究表明，射精后，精液对妊娠实现的显著生物学贡献被适时的IUI所取代。
