Elder J B, Ganguli P C, Gillespie I E
Lancet. 1979 May 12;1(8124):1005-6. doi: 10.1016/s0140-6736(79)92757-0.
Three patients with dyspeptic symptoms who were being treated with the H2-receptor blocking drug, cimetidine, were later found to have gastric carcinoma. It was not possible to determine whether the association was fortuitous, whether the drug had masked the neoplastic change, or whether it was involved in some other way. Repeated clinical and endoscopic evaluation is essential in patients on this treatment for any length of time.
三名正在接受H2受体阻断药西咪替丁治疗的消化不良症状患者，后来被发现患有胃癌。无法确定这种关联是偶然的，是药物掩盖了肿瘤变化，还是以其他某种方式与之有关。对于接受这种治疗任何时长的患者，反复进行临床和内镜评估至关重要。
