[S期和MIB1（Ki-67）增殖参数在淋巴结阴性乳腺癌中的预后意义]
[Prognostic significance of the S-phase and MIB1 (Ki-67) proliferation parameters in node-negative breast carcinoma].
作者信息
Harbeck N, Dettmar P, Thomssen Ch, Pache L, Ziffer P, Fizi K, Jänicke F, Nathrath W, Schmitt M, Graeff H
机构信息
Frauenklinik, Technischen Universität München.
出版信息
Gynakol Geburtshilfliche Rundsch. 1995;35 Suppl 1:142-7. doi: 10.1159/000272586.
OBJECTIVE
In 90 patients with primary node-negative breast carcinomas we compared the prognostic impact of total S-phase fraction (SPF) and MIB1 proliferation rate (MIB1-PR) after a median follow-up of 34 months (9-72 months).
METHODS
SPF was determined flow cytometrically and MIB1 (Ki-67) immunohistochemically in parallel-cut, paraffin-embedded tissue sections.
RESULTS
SPF was significantly correlated to tumor size and steroid hormone receptor status, MIB1-PR to grading. In univariate analysis both SPF and MIB1-PR were significant prognostic factors for disease-free survival. In multivariate analysis however, S-phase fraction was the only significant prognostic factor when compared to MIB1-PR, tumor size, steroid hormone receptor status, menopausal status, grading, lymph vessel invasion, and tumor necrosis.
CONCLUSIONS
In our study SPF was of higher prognostic strength and may therefore be better suited for clinical application than MIB1-PR in node-negative breast cancer.
目的
在90例原发性淋巴结阴性乳腺癌患者中，我们在中位随访34个月（9 - 72个月）后比较了总S期分数（SPF）和MIB1增殖率（MIB1 - PR）对预后的影响。
方法
在平行切割的石蜡包埋组织切片中，通过流式细胞术测定SPF，并通过免疫组织化学测定MIB1（Ki - 67）。
结果
SPF与肿瘤大小和类固醇激素受体状态显著相关，MIB1 - PR与分级相关。在单因素分析中，SPF和MIB1 - PR均为无病生存的显著预后因素。然而，在多因素分析中，与MIB1 - PR、肿瘤大小、类固醇激素受体状态、绝经状态、分级、淋巴管浸润和肿瘤坏死相比，S期分数是唯一显著的预后因素。
结论
在我们的研究中，SPF具有更高的预后强度，因此在淋巴结阴性乳腺癌中，与MIB1 - PR相比，可能更适合临床应用。
Zotero 插件