[人类乳腺癌的血管生成：异种移植中的新生血管形成及患者原位氧合]
[Angiogenesis of human breast cancers: neovascularization in xenotransplants and oxygenation in situ in patients].
作者信息
Runkel S, Wayss K, Melchert F
机构信息
Frauenklinik Mannheim, Klinische Fakultät, Universität Heidelberg.
出版信息
Gynakol Geburtshilfliche Rundsch. 1995;35 Suppl 1:68-72. doi: 10.1159/000272567.
OBJECTIVE
Recent reports have shown that vascularization of breast cancers is an independent prognostic parameter. Tumor growth and neovascularization were investigated in xenotransplants of breast cancers and tissue oxygenation was measured in patients with breast tumors.
METHODS
Tumor cells of the breast cancer MX-1 were implanted intradermally in 40 nude mice. Tumor growth and neovascularization were quantified microscopically. Tissue oxygenation was determined in 66 patients with breast tumors using the pO2-histography technique.
RESULTS AND CONCLUSION
The angiogenesis begins prior to tumor growth, is insufficient and leads to chaotic blood flow. This results in a heterogeneity of tissue oxygenation in breast cancers. Oxygenation at the tumor periphery appears to be of prognostic importance for clinical outcome of breast cancer.
目的
近期报告显示，乳腺癌血管生成是一个独立的预后参数。对乳腺癌异种移植瘤的肿瘤生长和新生血管形成进行了研究，并对乳腺肿瘤患者的组织氧合情况进行了测量。
方法
将乳腺癌MX-1细胞皮内植入40只裸鼠体内。通过显微镜对肿瘤生长和新生血管形成进行定量分析。使用pO2组织血氧定量技术对66例乳腺肿瘤患者的组织氧合情况进行测定。
结果与结论
血管生成在肿瘤生长之前就已开始，血管生成不足并导致血流紊乱。这导致了乳腺癌组织氧合的异质性。肿瘤周边的氧合情况似乎对乳腺癌的临床结局具有预后重要性。
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