Haworth S G, Reid L
Thorax. 1977 Apr;32(2):129-33. doi: 10.1136/thx.32.2.129.
The lungs of eight newborn infants who had died from pulmonary atresia were studied by quantitative morphometric techniques. It was established for the first time that the abnormal pattern of blood flow through the heart and great vessels in a fetus with pulmonary atresia is associated with impaired lung development as shown by arteries that are too few, too small, and with an abnormally thin muscle coat, although the distribution of muscle along the arterial pathway is normal. Differences between the cases in the degree of impairment of lung development could be detected and related to the degree of reduction in pressure and flow before birth in the individual case. Although blood flow through the pulmonary circulation is small before birth lung development seems sensitive to any further reduction.
对8例死于肺闭锁的新生儿的肺进行了定量形态计量学技术研究。首次证实，患有肺闭锁的胎儿心脏和大血管中异常的血流模式与肺发育受损有关，表现为动脉数量过少、管径过小且肌层异常薄，尽管沿动脉路径的肌肉分布正常。可以检测到病例之间肺发育受损程度的差异，并与个别病例出生前压力和血流量的降低程度相关。尽管出生前肺循环血流量很小，但肺发育似乎对任何进一步的降低都很敏感。
