Popuchiyev V V
Med Tr Prom Ekol. 1995(12):24-7.
The article describes possible application of quantitative functional and morphologic analysis to evaluation of chemical toxicity. Alteration caused by low doses of chemicals was proved to be mediated by neuroendocrine system. The regulatory disorders result from compromised interaction of cellular elements composing blood-tissue barriers in endocrine organs. The alteration caused by toxic chemicals could be lowered through the use of physiologic stabilization of endocrine system. Criteria to evaluate chemical toxicity are suggested.
本文描述了定量功能和形态学分析在化学毒性评估中的可能应用。低剂量化学物质引起的改变被证明是由神经内分泌系统介导的。调节紊乱是由于构成内分泌器官血组织屏障的细胞成分相互作用受损所致。通过内分泌系统的生理稳定作用，可以降低有毒化学物质引起的改变。文中提出了评估化学毒性的标准。
