Siderovski D P, Hessel A, Chung S, Mak T W, Tyers M
Quantitative Biology Laboratory, Amgen Institute, Toronto, Ontario, Canada.
Curr Biol. 1996 Feb 1;6(2):211-2. doi: 10.1016/s0960-9822(02)00454-2.
Organisms as diverse as fungi and humans use G-protein-coupled receptors to control signal transduction pathways responsive to various hormones, neuroregulatory molecules and other sensory stimuli. Continual stimulation of these receptors often leads to their desensitization, which is mediated in part by the consecutive actions of two families of proteins--the G-protein-coupled receptor kinases, which phosphorylate the agonist-occupied receptors, and the arrestin proteins, which subsequently bind to the receptors. We now present evidence that a group of proteins--the G0S8/Sst2p family--may be a third class of receptor-desensitizing factors.
从真菌到人类等多种生物都利用G蛋白偶联受体来控制对各种激素、神经调节分子及其他感觉刺激产生反应的信号转导途径。对这些受体的持续刺激常常导致它们脱敏，这部分是由两类蛋白质的连续作用介导的——G蛋白偶联受体激酶，其使被激动剂占据的受体磷酸化；以及抑制蛋白，其随后与受体结合。我们现在提供证据表明，一组蛋白质——G0S8/Sst2p家族——可能是第三类受体脱敏因子。
