McGuire P K, Silbersweig D A, Frith C D
Department of Psychological Medicine, Institute of Psychiatry, London, UK.
Brain. 1996 Jun;119 ( Pt 3):907-17. doi: 10.1093/brain/119.3.907.
The neural correlates of verbal self-monitoring were examined by measuring the response to alterations in auditory verbal feedback while subjects read aloud. Six normal subjects were studied with PET, using H2(15)O as a tracer of regional CBF. There was no difference between the temporal cortical response to reading aloud (and hearing one's own speech) and reading silently while hearing the words spoken by someone else. Distortion of subjects' speech (by pitch elevation) while they read aloud led to a bilateral activation of lateral temporal cortex, with a greater response on the right side than the left. A similar pattern of activation was evident when subjects read aloud, but the words they heard were spoken by someone else. These data suggest that (i) self-and externally generated speech are processed in similar regions of temporal cortex, and (ii) the monitoring of self-generated speech involves the temporal cortex bilaterally, in areas associated with the processing of speech which has been generated externally.
通过在受试者大声朗读时测量对听觉言语反馈改变的反应，研究了言语自我监测的神经关联。使用正电子发射断层扫描（PET）对6名正常受试者进行研究，以H2(15)O作为局部脑血流量（CBF）的示踪剂。颞叶皮质对大声朗读（以及听到自己的讲话）和默读时听到别人讲话的反应没有差异。受试者大声朗读时其言语的扭曲（通过音高升高）导致颞叶外侧皮质的双侧激活，右侧的反应比左侧更大。当受试者大声朗读但听到的单词由别人说出时，也出现了类似的激活模式。这些数据表明：（i）自我产生和外部产生的言语在颞叶皮质的相似区域进行处理；（ii）对自我产生言语的监测涉及双侧颞叶皮质，在与外部产生言语处理相关的区域。
