Horner R D, Bennett C L, Achenbach C, Rodriguez D, Adams J, Gilman S C, Cohn S E, Dickinson G M, DeHovitz J A, Weinstein R A
Department of Medicine, Lakeside VA Medical Center (111), Chicago, IL 60611, USA.
J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Aug 1;12(4):379-85. doi: 10.1097/00042560-199608010-00008.
To determine whether patient and hospital characteristics were significantly associated with variations in Pneumocystis carinii (PCP) care and outcomes, we analyzed the use of diagnostic tests, intensive care units (ICUs), anti-PCP medications for persons hospitalized with human immunodeficiency virus (HIV)-related PCP, and hospital discharge status. We conducted retrospective chart reviews of a cohort of 2,174 patients with PCP hospitalized in 1987-1990. Outcomes included process of care for PCP and in-hospital mortality rates. Persons with PCP who were more severely ill at admission were more likely to have early medical care, to receive care in an intensive care unit, and to die in hospital. After we adjusted for differences in this severity of illness, we noted that Medicaid patients, injection drug users (IDUs), and patients treated at VA or county hospitals were significantly less likely than others to have diagnostic bronchoscopies and that persons covered by Medicaid, with a previous diagnosis of acquired immunodeficiency syndrome (AIDS), who did not receive prior zidovudine (AZT) or who received care in a VA hospital had the highest chances of in-hospital death. Insurance and risk group characteristics, severity of illness, and hospital characteristics appear to be the most important determinants of the intensity and timing of medical care and outcomes among patients hospitalized with PCP.
为了确定患者和医院特征是否与卡氏肺孢子虫肺炎(PCP)的治疗及预后差异显著相关,我们分析了诊断检测的使用情况、重症监护病房(ICU)的使用情况、针对因人类免疫缺陷病毒(HIV)相关PCP住院患者的抗PCP药物使用情况以及医院出院状态。我们对1987 - 1990年住院的2174例PCP患者进行了回顾性病历审查。预后包括PCP的治疗过程和住院死亡率。入院时病情较重的PCP患者更有可能接受早期医疗护理、在重症监护病房接受治疗并在医院死亡。在我们对病情严重程度的差异进行调整后,我们注意到医疗补助患者、注射吸毒者(IDU)以及在退伍军人事务部(VA)医院或县医院接受治疗的患者进行诊断性支气管镜检查的可能性明显低于其他人,并且医疗补助覆盖的患者、既往诊断为获得性免疫缺陷综合征(AIDS)的患者、未接受过齐多夫定(AZT)治疗的患者或在VA医院接受治疗的患者住院死亡几率最高。保险和风险组特征、病情严重程度以及医院特征似乎是PCP住院患者医疗护理强度和时机以及预后的最重要决定因素。