p53活性与化疗 - Suppr

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p53 activity and chemotherapy.

作者信息

Delia D, Mizutani S, Lamorte G, Goi K, Iwata S, Pierotti M A

出版信息

Nat Med. 1996 Jul;2(7):724-5. doi: 10.1038/nm0796-724.

DOI:10.1038/nm0796-724

PMID:8673907

Abstract

摘要

相似文献

p53 activity and chemotherapy.p53活性与化疗

Nat Med. 1996 Jul;2(7):724-5. doi: 10.1038/nm0796-724.

Paclitaxel selects for mutant or pseudo-null p53 in drug resistance associated with tubulin mutations in human cancer.在与人类癌症中微管蛋白突变相关的耐药性方面，紫杉醇会选择突变型或假无效型p53。

Oncogene. 2000 Jun 22;19(27):3078-85. doi: 10.1038/sj.onc.1203642.

A serine 37 mutation associated with two missense mutations at highly conserved regions of p53 affect pro-apoptotic genes expression in a T-lymphoblastoid drug resistant cell line.与p53高度保守区域的两个错义突变相关的丝氨酸37突变影响T淋巴母细胞耐药细胞系中促凋亡基因的表达。

Oncogene. 2000 Oct 19;19(44):5098-105. doi: 10.1038/sj.onc.1203848.

miR-203 reverses chemoresistance in p53-mutated colon cancer cells through downregulation of Akt2 expression.miR-203 通过下调 Akt2 表达逆转 p53 突变型结肠癌细胞的化疗耐药性。

Cancer Lett. 2011 May 1;304(1):52-9. doi: 10.1016/j.canlet.2011.02.003. Epub 2011 Feb 26.

p38 MAPK-induced MDM2 degradation confers paclitaxel resistance through p53-mediated regulation of EGFR in human lung cancer cells.p38丝裂原活化蛋白激酶诱导的MDM2降解通过p53介导的人肺癌细胞中表皮生长因子受体的调控赋予紫杉醇抗性。

Oncotarget. 2016 Feb 16;7(7):8184-99. doi: 10.18632/oncotarget.6945.

Simultaneous genetic chemoprotection of normal marrow cells and genetic chemosensitization of breast cancer cells in a mouse cancer gene therapy model.在小鼠癌症基因治疗模型中对正常骨髓细胞进行同步基因化学保护及对乳腺癌细胞进行基因化学增敏

Clin Cancer Res. 1997 Feb;3(2):281-6.

The effect of p53-function on the sensitivity to paclitaxel with or without hyperthermia in human colorectal carcinoma cells.p53功能对人结肠癌细胞在有或无热疗情况下对紫杉醇敏感性的影响。

Int J Oncol. 2000 Apr;16(4):739-44. doi: 10.3892/ijo.16.4.739.

Overexpression of p21(waf1) decreases G2-M arrest and apoptosis induced by paclitaxel in human sarcoma cells lacking both p53 and functional Rb protein.p21（waf1）的过表达可减少在同时缺乏p53和功能性Rb蛋白的人肉瘤细胞中由紫杉醇诱导的G2-M期阻滞和细胞凋亡。

Mol Pharmacol. 1999 Jun;55(6):1088-93. doi: 10.1124/mol.55.6.1088.

Effect of paclitaxel pretreatment on radiation-induced p53-dependent apoptosis.紫杉醇预处理对辐射诱导的p53依赖性细胞凋亡的影响。

Anticancer Res. 1999 Nov-Dec;19(6B):5101-10.

p53 status and its in vitro relationship to radiosensitivity and chemosensitivity in lung cancer.肺癌中p53状态及其与放射敏感性和化学敏感性的体外关系

Anticancer Res. 2003 Mar-Apr;23(2B):1207-12.

引用本文的文献

The Tip of an Iceberg: Replication-Associated Functions of the Tumor Suppressor p53.冰山一角：肿瘤抑制因子p53的复制相关功能

Cancers (Basel). 2018 Jul 28;10(8):250. doi: 10.3390/cancers10080250.

The role of Six1 signaling in paclitaxel-dependent apoptosis in MCF-7 cell line.Six1信号通路在MCF-7细胞系中紫杉醇依赖性凋亡中的作用。

Bosn J Basic Med Sci. 2016 Jan 1;16(1):28-34. doi: 10.17305/bjbms.2016.674.

Inactivation of wild-type p53 by a dominant negative mutant renders MCF-7 cells resistant to tubulin-binding agent cytotoxicity.一种显性负性突变体使野生型p53失活，从而使MCF-7细胞对微管蛋白结合剂的细胞毒性产生抗性。

Br J Cancer. 2001 Sep 14;85(6):902-8. doi: 10.1054/bjoc.2001.2017.

Therapy effect of either paclitaxel or cyclophosphamide combination treatment in patients with epithelial ovarian cancer and relation to TP53 gene status.紫杉醇或环磷酰胺联合治疗对上皮性卵巢癌患者的疗效及其与TP53基因状态的关系。

Br J Cancer. 1998 Aug;78(3):375-81. doi: 10.1038/bjc.1998.502.

Mutation of the p53 gene in human astrocytic tumours correlates with increased resistance to DNA-damaging agents but not to anti-microtubule anti-cancer agents.人类星形细胞瘤中p53基因的突变与对DNA损伤剂的耐药性增加相关，但与抗微管抗癌剂的耐药性无关。

Br J Cancer. 1998 Feb;77(4):547-51. doi: 10.1038/bjc.1998.88.

Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53.药物诱导肝癌细胞凋亡是由CD95（APO-1/Fas）受体/配体系统介导的，并且涉及野生型p53的激活。

J Clin Invest. 1997 Feb 1;99(3):403-13. doi: 10.1172/JCI119174.

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