Ohsumi T, Seiji M
Tohoku J Exp Med. 1977 Apr;121(4):355-64. doi: 10.1620/tjem.121.355.
The authors reported in 1972 a statistical study based on 501 cases of malignant melanoma. As continouous study this review was carried out on 456 cases of melanoma which were reported during six years between 1970 and 1976. These two studies showed quite similar results as follows: (1) Yearly incidnece of malignant melanoma indicated a definite upward trend and the average number of patients was 71.1 per year. (2) Distribution by age showed one peak in the seventh decade. (3) Sex ratio was 1.1: 1. (4) The number of cases per total population in Japan showed great increase in over fifth decades and two peaks in the 7th and 8th decades. (5) Average age of the onset of all melanoma was 51.6 years old, while, that of brain and spinal cord melanoma was 25.4 years old. In the skin melanoma with preexisting pigmented skin lesions, the median age of the onset of primary melanoma on the foot was 38.7 years old and that of originated melanoma except foot was 65.9 years old. (6) Incidence of the melanoma was high in the sole considering the number of melanocytes per unit skin area.
作者于1972年报告了一项基于501例恶性黑色素瘤的统计研究。作为一项持续研究，本综述对1970年至1976年这六年期间报告的456例黑色素瘤病例进行了分析。这两项研究显示出相当相似的结果如下：（1）恶性黑色素瘤的年发病率呈明显上升趋势，每年的患者平均人数为71.1人。（2）年龄分布在第七个十年出现一个高峰。（3）性别比为1.1:1。（4）日本每总人口中的病例数在五十多岁以后大幅增加，在第七和第八个十年出现两个高峰。（5）所有黑色素瘤的平均发病年龄为51.6岁，而脑和脊髓黑色素瘤的平均发病年龄为25.4岁。在有色素沉着皮肤病变的皮肤黑色素瘤中，足部原发性黑色素瘤的中位发病年龄为38.7岁，非足部起源的黑色素瘤的中位发病年龄为65.9岁。（6）考虑到每单位皮肤面积的黑素细胞数量，黑色素瘤在足底的发病率较高。
