艾滋病患者中同种抗体水平正常，但针对ABO组织血型抗原的潜在自身反应性抗体水平升高。

Normal levels of allo- but increased levels of potentially autoreactive antibodies against ABO histo-blood group antigens in AIDS patients.

作者信息

Friedli F, Rieben R, Wegmüller E, Moerenhout M, Nydegger U E

机构信息

Medical Department, Regional Hospital Interlaken, Bern, Switzerland.

出版信息

Clin Immunol Immunopathol. 1996 Jul;80(1):96-100. doi: 10.1006/clin.1996.0099.

DOI:10.1006/clin.1996.0099

PMID:8674246

Abstract

The aim of our study was to investigate the immune response of human immunodeficiency virus (HIV)-infected patients in relation to the naturally occurring ABO histo-blood group antibodies. Despite markedly elevated levels of total IgM/G/A, anti-A/B isotypes revealed no significant different mean levels in AIDS patients compared to controls. However, 12 A-type AIDS sera out of 17 (70%) had anti-A IgA levels that were increased by >2 SD above normal range; anti-A IgM and anti-A IgG were increased in 7/17 (41%) and 2/17 (12%) of A-type AIDS sera, respectively. We conclude that the specific response to ABO histo-blood group antigens remains at levels similar to normal and does not follow hypergammaglobulinemia. As yet, certain A-type AIDS patients may form auto-anti-A as suggested by a portion of our data.

摘要

我们研究的目的是调查人类免疫缺陷病毒（HIV）感染患者针对自然存在的ABO组织血型抗体的免疫反应。尽管总IgM/G/A水平显著升高，但与对照组相比，AIDS患者的抗A/B同种型平均水平没有显著差异。然而，17份A型AIDS血清中有12份（70%）的抗A IgA水平升高超过正常范围2个标准差以上；抗A IgM和抗A IgG分别在7/17（41%）和2/17（12%）的A型AIDS血清中升高。我们得出结论，对ABO组织血型抗原的特异性反应仍维持在与正常相似的水平，并不随高球蛋白血症而变化。根据我们的部分数据表明，某些A型AIDS患者可能会形成自身抗A抗体。