Liu Y J, Saini A, Cohen D J, Ooi B S
Department of Internal Medicine, V.A. Medical Center, Washington, DC 20422, USA.
Mol Cell Endocrinol. 1995 Oct 30;114(1-2):187-92. doi: 10.1016/0303-7207(95)96799-n.
Macrophages have been show to be of importance in three areas of pathology in the diabetic state: (a) in the destruction of the beta cells of the pancreas; (b) in the pathogenesis of the microvascular lesions; and (c) in the atherosclerotic lesion which is a common complication of diabetes. However, there is only scanty information on the behavior of the macrophage in the hyperglycemic environment. The present study investigates the growth of WEHI-3 monocytes/macrophages and the proliferative response of splenic macrophages to colony stimulating factor-1 when cultured in media containing high glucose concentrations. The results of the study show that hyperglycemia increases the proliferation of these macrophages; this effect is not mediated by the effect of osmolality since mannitol and L-glucose failed to produce a similar result. These findings suggest that alterations of macrophage physiology may be an important component of the diabetic state; such alterations may have a role in the production of some of the lesions found in diabetes mellitus.
（a）在胰腺β细胞的破坏中；（b）在微血管病变的发病机制中；以及（c）在作为糖尿病常见并发症的动脉粥样硬化病变中。然而，关于巨噬细胞在高血糖环境中的行为的信息却很少。本研究调查了WEHI-3单核细胞/巨噬细胞在含高糖浓度的培养基中培养时的生长情况以及脾巨噬细胞对集落刺激因子-1的增殖反应。研究结果表明，高血糖会增加这些巨噬细胞的增殖；这种作用不是由渗透压的影响介导的，因为甘露醇和L-葡萄糖未能产生类似的结果。这些发现表明，巨噬细胞生理学的改变可能是糖尿病状态的一个重要组成部分；这种改变可能在糖尿病中发现的一些病变的产生中起作用。
