老年个体中T细胞受体V区基因片段频率
T cell receptor V-segment frequencies in aged individuals.
作者信息
Ruiz M, Esparza B, Barranquero M, Sabino E, Merino F
机构信息
Department of Physiology, School of Medicine, Universidad del País Vasco, Bilbao, Spain.
出版信息
Immunol Invest. 1996 Jan-Mar;25(1-2):111-4. doi: 10.3109/08820139609059295.
PMID:8675227
Abstract
The T V alpha and V beta cell specificities repertoire usage in aging subjects was studied by the use of seven different monoclonal antibodies specific for defined regions of the T cell receptor (TCR). Except for the V beta 8 subfamily, no differences were observed in the frequency of T cells bearing selected V alpha beta epitopes, between old and control subjects.
摘要
通过使用七种针对T细胞受体（TCR）特定区域的不同单克隆抗体，研究了衰老受试者中T细胞α和β细胞特异性谱库的使用情况。除了Vβ8亚家族外，在老年受试者和对照受试者之间，携带选定Vαβ表位的T细胞频率没有观察到差异。
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