Pabon J E, Bird J S, Li X, Huang Z H, Lei Z M, Sanfilippo J S, Yussman M A, Rao C V
Department of Obstetrics and Gynecology, University of Louisville Medical Center, KY 40292, USA.
J Clin Endocrinol Metab. 1996 Jul;81(7):2738-41. doi: 10.1210/jcem.81.7.8675605.
Normal human skin contains a major 4.5 kb and several minor mRNA transcripts and a 66 kDa protein of luteinizing hormone (LH)/chorionic gonadotropin (hCG) receptors which are capable of binding exogenous 125I-hCG. The distribution of receptor transcripts and receptor protein are the highest in epidermis followed by hair follicles, sebaceous and sweat glands. LH/hCG receptors are co-localized with androgen receptors in all the skin appendages. These data are the first demonstration of skin containing LH/hCG receptors and would suggest that LH and hCG may regulate skin functions.
正常人类皮肤含有一条主要的4.5 kb以及几条次要的mRNA转录本，还有一种66 kDa的促黄体生成素（LH）/绒毛膜促性腺激素（hCG）受体蛋白，这些受体能够结合外源性125I-hCG。受体转录本和受体蛋白的分布在表皮中最高，其次是毛囊、皮脂腺和汗腺。LH/hCG受体在所有皮肤附属器中都与雄激素受体共定位。这些数据首次证明皮肤含有LH/hCG受体，这表明LH和hCG可能调节皮肤功能。
