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本文引用的文献

1
Efficient tumor cell lysis mediated by a bispecific single chain antibody expressed in Escherichia coli.由在大肠杆菌中表达的双特异性单链抗体介导的高效肿瘤细胞裂解。
J Immunol. 1994 Jun 1;152(11):5368-74.
2
Antitumor x anti-CD3 bifunctional antibodies redirect T-cells activated in vivo with staphylococcal enterotoxin B to neutralize pulmonary metastases.抗肿瘤x抗CD3双功能抗体将体内被葡萄球菌肠毒素B激活的T细胞重新定向，以中和肺转移灶。
Cancer Res. 1994 May 15;54(10):2738-43.
3
Principles for adoptive T cell therapy of human viral diseases.人类病毒性疾病过继性T细胞疗法的原则
Annu Rev Immunol. 1995;13:545-86. doi: 10.1146/annurev.iy.13.040195.002553.
4
Hepatitis B virus immunopathogenesis.乙型肝炎病毒免疫发病机制
Annu Rev Immunol. 1995;13:29-60. doi: 10.1146/annurev.iy.13.040195.000333.
5
Staphylococcal enterotoxin B-activated T cells can be redirected to inhibit multicycle virus replication.葡萄球菌肠毒素B激活的T细胞可被重定向以抑制多轮病毒复制。
J Immunol. 1995 Jul 15;155(2):759-65.
6
Retargeting of CTL by an efficiently refolded bispecific single-chain Fv dimer produced in bacteria.
J Immunol. 1995 May 1;154(9):4576-82.
7
Hybrid hybridomas and their use in immunohistochemistry.杂交杂交瘤及其在免疫组织化学中的应用。
Nature. 1983;305(5934):537-40. doi: 10.1038/305537a0.
8
Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface.流感病毒M2蛋白是一种表达于被感染细胞表面的整合膜蛋白。
Cell. 1985 Mar;40(3):627-33. doi: 10.1016/0092-8674(85)90211-9.
9
Specific targeting of cytotoxic T cells by anti-T3 linked to anti-target cell antibody.与抗靶细胞抗体相连的抗T3对细胞毒性T细胞的特异性靶向作用。
Nature. 1985;316(6026):354-6. doi: 10.1038/316354a0.
10
Human T cells targeted with anti-T3 cross-linked to antitumor antibody prevent tumor growth in nude mice.用抗T3交联到抗肿瘤抗体靶向的人T细胞可防止裸鼠体内肿瘤生长。
J Immunol. 1987 Jun 1;138(11):4018-22.

一种识别甲型流感病毒M2蛋白的双特异性抗体可重定向效应细胞以在体外抑制病毒复制。

A bispecific antibody recognizing influenza A virus M2 protein redirects effector cells to inhibit virus replication in vitro.

作者信息

Fernandez-Sesma A, Schulman J L, Moran T M

机构信息

Microbiology Department, Mount Sinai Medical Center, New York, New York 10029, USA.

出版信息

J Virol. 1996 Jul;70(7):4800-4. doi: 10.1128/JVI.70.7.4800-4804.1996.

DOI:10.1128/JVI.70.7.4800-4804.1996
PMID:8676511
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC190421/
Abstract

Bispecific antibodies can be used to redirect cytotoxic T cells to kill virus-infected cells, overriding the need for major histocompatibility complex restriction. We produced a bispecific antibody (3F12) which binds influenza virus M2 protein and the T-cell receptor and can redirect staphylococcal enterotoxin B-activated T cells to kill influenza virus-infected cells and inhibit virus replication in vitro.

摘要

双特异性抗体可用于重定向细胞毒性T细胞以杀死病毒感染细胞，从而无需主要组织相容性复合体限制。我们制备了一种双特异性抗体（3F12），它能结合流感病毒M2蛋白和T细胞受体，并能重定向葡萄球菌肠毒素B激活的T细胞以杀死流感病毒感染细胞并在体外抑制病毒复制。