环境太阳紫外线辐射对眼鳞状细胞癌发病率的影响。
Effect of ambient solar ultraviolet radiation on incidence of squamous-cell carcinoma of the eye.
作者信息
Newton R, Ferlay J, Reeves G, Beral V, Parkin D M
机构信息
Imperial Cancer Research Fund, Cancer Epidemiology Unit, Radcliffe Infirmary, Oxford.
出版信息
Lancet. 1996 May 25;347(9013):1450-1. doi: 10.1016/s0140-6736(96)91685-2.
BACKGROUND
We have investigated the geographic distribution of squamous-cell carcinoma of the eye to assess whether solar ultraviolet light is a risk factor for this disease.
METHODS
We used routinely collected population-based cancer incidence data and published measurements of ambient solar ultraviolet light in our analysis.
FINDINGS
The incidence of squamous-cell carcinoma of the eye declined by 49% of each 10 degrees increase in latitude (p < 0.0001), falling from more than 12 cases per million per year in Uganda (latitude 0.3(0)) to less than O.2 per million per year in the UK (latitude > 50(0)). Solar ultraviolet radiation decreases with increasing latitude, and the incidence of squamous-cell carcinoma of the eye decreased by 29% per unit reduction in ultraviolet exposure (p < 0.0001).
INTERPRETATION
Our results are compatible with the hypothesis that exposure to solar ultraviolet light is an important cause of squamous-cell carcinoma of the eye.
背景
我们研究了眼部鳞状细胞癌的地理分布，以评估太阳紫外线是否为此病的一个风险因素。
方法
我们在分析中使用了常规收集的基于人群的癌症发病率数据以及已发表的环境太阳紫外线测量数据。
研究结果
眼部鳞状细胞癌的发病率随纬度每升高10度下降49%（p<0.0001），从乌干达每年每百万超过12例（纬度0.3(0)）降至英国每年每百万少于0.2例（纬度>50(0)）。太阳紫外线辐射随纬度升高而降低，眼部鳞状细胞癌的发病率随紫外线暴露每减少一个单位下降29%（p<0.0001）。
解读
我们的结果与以下假设相符，即暴露于太阳紫外线是眼部鳞状细胞癌的一个重要病因。
Zotero 插件