Oliviero G, Constans P, Caby I, De Rohan Chabot P, Lacherade J C
Service de Pneumologie et Médecine Interne, CHG Longjumeau.
Rev Mal Respir. 1995;12(6):631-3.
A young man without any past history of note had taken isotretinoin for disfiguring acne before the summer season. He presented with a severe bilateral pneumonia, associated with dyspnoea two months after the start of treatment. On the pulmonary radiography there was a bilateral ground glass appearance which was worse on the right. The elevated level of eosinophils (54% in 564,000 cells/ml) in the alveolar lavage lead to a diagnosis of allergic pneumonia. The rapidly favourable outcome following the cessation of the medication and with the addition of corticosteroids seemed to us a supplementary argument in favour of a diagnosis of eosinophilic pneumonia, due to isotretinoin which seemed the primary initiating factor.
一名无显著既往病史的年轻男性在夏季来临前服用异维A酸治疗毁容性痤疮。治疗开始两个月后，他出现严重的双侧肺炎，并伴有呼吸困难。肺部X光检查显示双侧磨玻璃样外观，右侧更为严重。肺泡灌洗中嗜酸性粒细胞水平升高（564,000个细胞/毫升中占54%），从而诊断为过敏性肺炎。停药并加用皮质类固醇后病情迅速好转，在我们看来，这进一步支持了嗜酸性粒细胞性肺炎的诊断，异维A酸似乎是主要的起始因素。
