FLT3酪氨酸激酶受体的表达与信号转导
Expression and signal transduction of the FLT3 tyrosine kinase receptor.
作者信息
Rosnet O, Bühring H J, deLapeyrière O, Beslu N, Lavagna C, Marchetto S, Rappold I, Drexler H G, Birg F, Rottapel R, Hannum C, Dubreuil P, Birnbaum D
机构信息
Laboratory of Molecular Oncology, U.119 INSERM, Marseille, France.
出版信息
Acta Haematol. 1996;95(3-4):218-23. doi: 10.1159/000203881.
FLT3 is a receptor tyrosine kinase of 130-55 kDa expressed on normal bone marrow stem and early progenitor cells and on leukemic blasts from patients with acute leukemias. The FLT3 ligand, FL, is a new cytokine which acts on hematopoietic progenitors in synergy with other cytokines. FLT3 transduces FL-mediated signal through interaction with a number of cytoplasmic substrates.
FLT3是一种130 - 55 kDa的受体酪氨酸激酶，在正常骨髓干细胞、早期祖细胞以及急性白血病患者的白血病原始细胞上表达。FLT3配体（FL）是一种新型细胞因子，它与其他细胞因子协同作用于造血祖细胞。FLT3通过与多种细胞质底物相互作用来转导FL介导的信号。
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