Bosman C, Fusilli S, Bisceglia M, Musto P, Corsi A
Dipartimento di Medicina Sperimentale e Patologia, Università La Sapienza, Policlinico Umberto I, Roma, Italy.
Acta Haematol. 1996;96(1):50-6. doi: 10.1159/000203715.
We report on a morphologic variant of multiple myeloma, identified in a 39-year-old man, with osteolytic lesions in two ribs and three lumbar vertebrae. Serum electrophoresis was normal and immunofixation of serum and urine was negative. Histologic examination of a resected rib revealed a homogeneous population of neoplastic plasma cells with granular and eosinophilic cytoplasm. Immunohistochemical stains showed monoclonality for lambda light chain and negativity for all heavy chains. At the ultrastructural level, the cytoplasm of the neoplastic plasma cells was almost totally occupied by round and elongated mitochondria, pushing the rough endoplasmic reticulum to the periphery. To the best of our knowledge, only two similar cases have been reported in the literature so far. The usefulness of obtaining a clinicopathologic correlation for the behaviour of this extremely rare variant of multiple myeloma is discussed.
我们报告了一例多发性骨髓瘤的形态学变异型，该病例为一名39岁男性，其两根肋骨和三个腰椎出现溶骨性病变。血清电泳正常，血清和尿液免疫固定均为阴性。对切除肋骨的组织学检查显示，肿瘤性浆细胞均一，细胞质呈颗粒状且嗜酸性。免疫组化染色显示λ轻链单克隆性，所有重链均为阴性。在超微结构水平上，肿瘤性浆细胞的细胞质几乎完全被圆形和细长形线粒体占据，将粗面内质网挤至周边。据我们所知，迄今为止文献中仅报道了两例类似病例。本文讨论了对这种极其罕见的多发性骨髓瘤变异型的行为进行临床病理相关性分析的作用。
