Cauffield J S, Gums J G, Curry R W
University of Florida College of Medicine, Gainesville, USA.
Am Fam Physician. 1996 Jul;54(1):263-6, 269-70.
Intended for the treatment of hypertension, alpha blockers offer advantages in treating patients who also have other risk factors for coronary artery disease. Alpha blockers lower blood pressure by decreasing vascular resistance and are effective for the treatment of mild to moderate hypertension. In addition, alpha blockers have beneficial effects on lipid levels; they increase high-density lipoprotein levels and decrease total cholesterol, low-density lipoprotein and triglyceride levels. Alpha blockers do not induce glucose intolerance or hyperinsulinemia. Although they appear to decrease left ventricular mass, the clinical significance of this action is unknown. Alpha blockers are also effective for improving the symptoms of benign prostatic hypertrophy, although surgery is recommended for patients with severe symptoms.
α受体阻滞剂旨在治疗高血压，对于患有冠状动脉疾病其他危险因素的患者，它在治疗中具有优势。α受体阻滞剂通过降低血管阻力来降低血压，对轻度至中度高血压的治疗有效。此外，α受体阻滞剂对血脂水平有有益影响；它们可提高高密度脂蛋白水平，并降低总胆固醇、低密度脂蛋白和甘油三酯水平。α受体阻滞剂不会诱发葡萄糖不耐受或高胰岛素血症。尽管它们似乎能减少左心室质量，但这一作用的临床意义尚不清楚。α受体阻滞剂对改善良性前列腺增生的症状也有效，不过对于症状严重的患者，建议进行手术治疗。
