Babb R R
Gastroenterology Division, Palo Alto Medical Clinic, California 94301, USA.
Am J Gastroenterol. 1996 Jul;91(7):1309-11.
Radiation therapy of cancers in the pelvic region may lead to radiation proctitis. Radiation injury to the rectal wall eventually causes connective tissue fibrosis and obliterative endarteritis with subsequent local tissue ischemia. Patients with radiation proctitis may be minimally ill and heal spontaneously. However, symptoms of proctitis may persist, and the disease progresses to chronic bleeding and/or stricture and fistula formation. Medical therapy is often unsuccessful, and surgery is eventually required. Because of numerous postoperative complications and no guarantee of success, surgery should only be done as a last resort.
盆腔区域癌症的放射治疗可能会导致放射性直肠炎。直肠壁的辐射损伤最终会导致结缔组织纤维化和闭塞性动脉内膜炎，随后引起局部组织缺血。放射性直肠炎患者可能病情轻微并可自愈。然而，直肠炎症状可能会持续存在，疾病会发展为慢性出血和/或狭窄以及瘘管形成。药物治疗往往不成功，最终需要进行手术。由于术后并发症众多且无法保证成功，手术应仅作为最后手段进行。
