Tanaka K, Shiraishi K, Sakamoto A, Okubo Y, Fukuda Y, Fukahori S, Jojima H, Osabe S, Honda J, Natori H, Oizumi K
First Dept. of Internal Medicine, Kurume University School of Medicine, Japan.
Gan To Kagaku Ryoho. 1996 Jun;23(7):863-9.
We measured soluble interleukin-2 receptor (sIL-2R) levels in the cerebrospinal fluid (CSF) of patients with hematological malignancies especially, adult T-cell leukemia (ATL) and non-Hodgkin's lymphoma (NHL) with or without meningeal infiltration. CSF levels of sIL-2R were significantly higher in patients with ATL and NHL with meningeal infiltration than in patients with both diseases without meningeal infiltration. The sIL-2R levels in CSF were elevated in 4/4 ATL patients (100%) and 3/13 NHL patients (23%) with meningeal infiltration. CSF levels of sIL-2R from ATL patients with meningeal infiltration had a tendency to elevate in correlation with numbers of mononuclear cells and lactic dehydrogenase (LDH) in CSF. However, these had no correlation with serum levels of sIL-2R. Therefore, sIL-2 levels in CSF may be useful in the diagnosis of meningeal infiltration in patients with ATL, are probably specific markers for meningeal infiltration of ATL.
我们检测了血液系统恶性肿瘤患者，尤其是成人T细胞白血病（ATL）和有或无脑膜浸润的非霍奇金淋巴瘤（NHL）患者脑脊液（CSF）中可溶性白细胞介素-2受体（sIL-2R）的水平。有脑膜浸润的ATL和NHL患者脑脊液中sIL-2R水平显著高于无脑膜浸润的这两种疾病患者。4/4（100%）有脑膜浸润的ATL患者和3/13（23%）有脑膜浸润的NHL患者脑脊液中sIL-2R水平升高。有脑膜浸润的ATL患者脑脊液中sIL-2R水平有随脑脊液中单核细胞数量和乳酸脱氢酶（LDH）升高的趋势。然而，这些与血清sIL-2R水平无关。因此，脑脊液中的sIL-2水平可能有助于诊断ATL患者的脑膜浸润，可能是ATL脑膜浸润的特异性标志物。
