Horiuchi M, Tamura Y
Dept. of Otolaryngology, Tokai University School of Medicine, Japan.
Gan To Kagaku Ryoho. 1996 Jun;23(7):949-56.
The clinical and histological factors predicting survival of patients with head and neck cancer were discussed. Recent reports with multivariate analysis focusing on clinical prognostic factors revealed that staging of nodal metastases is most significant. Number and size of metastatic nodes can be evaluated as factors to predict the outcome of advanced cancer. The number of positive nodes over 4 may be associated with poor prognosis. A scoring system of histological grading has been developed at this primary site. The mode of invasion or depth of invasion of cancer may predict the metastases to regional nodes. The research on molecular pathology is ongoing in head and neck cancer. No independent prognostic factor is yet available in clinical practice.
讨论了预测头颈癌患者生存的临床和组织学因素。近期关于聚焦临床预后因素的多变量分析报告显示，淋巴结转移分期最为重要。转移淋巴结的数量和大小可作为预测晚期癌症预后的因素进行评估。阳性淋巴结数量超过4个可能与预后不良相关。已针对该原发部位制定了组织学分级评分系统。癌症的侵袭方式或侵袭深度可能预测区域淋巴结转移。头颈癌的分子病理学研究正在进行中。临床实践中尚无独立的预后因素。
