Margolis D J, Attie M, Leyden J J
Department of Dermatology, University of Pennsylvania Medical Center, Philadelphia, USA.
Arch Dermatol. 1996 Jul;132(7):769-74. doi: 10.1001/archderm.1996.03890310053007.
To examine the effects of isotretinoin on bone mineralization and other markers of calcium homeostasis in individuals receiving isotretinoin for routine therapy for severe acne vulgaris.
Cohort study.
An academic medical center.
Twenty individuals receiving isotretinoin for severe acne vulgaris.
None.
The primary outcome was the change in bone mineralization as measured by dual-energy x-ray absorptiometry of the lumbar spine and hip before and after isotretinoin therapy. Additional measurements included serum osteocalcin, calcium, 25-dihydroxyvitamin D, 1,25-dihydroxyvitamin D, and intact parathyroid hormone and urine hydroxyproline or calcium.
No changes were noted in bone mineralization of the lumbar spine or hip. Furthermore, no alterations were noted in serum measurements of osteocalcin, calcium, 25-dihydroxyvitamin D, intact parathyroid hormone, or urine measurements of hydroxyproline or calcium. A statistically significant change was noted in 1,25-dihydroxyvitamin D when serum from before and after isotretinoin therapy was compared.
The use of isotretinoin for 20 weeks for the treatment of severe acne vulgaris does not appear to have any substantial adverse effect on bone mineralization.
研究异维A酸对重度寻常痤疮患者常规治疗中骨矿化及其他钙稳态标志物的影响。
队列研究。
一所学术医疗中心。
20名接受异维A酸治疗重度寻常痤疮的患者。
无。
主要结局是异维A酸治疗前后通过腰椎和髋部双能X线吸收法测量的骨矿化变化。其他测量指标包括血清骨钙素、钙、25-二羟维生素D、1,25-二羟维生素D、完整甲状旁腺激素以及尿羟脯氨酸或钙。
腰椎或髋部的骨矿化未见变化。此外，血清骨钙素、钙、25-二羟维生素D、完整甲状旁腺激素的测量值以及尿羟脯氨酸或钙的测量值均未见改变。比较异维A酸治疗前后的血清时，1,25-二羟维生素D有统计学意义的变化。
使用异维A酸治疗重度寻常痤疮20周似乎对骨矿化没有任何实质性不良影响。
