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A high-resolution linkage map of the tight skin 2 (Tsk2) locus: a mouse model for scleroderma (SSc) and other cutaneous fibrotic diseases.

作者信息

Christner P J, Siracusa L D, Hawkins D F, McGrath R, Betz J K, Ball S T, Jimenez S A, Peters J

机构信息

Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

出版信息

Mamm Genome. 1996 Aug;7(8):610-2. doi: 10.1007/s003359900181.

DOI:10.1007/s003359900181
PMID:8678985
Abstract
摘要

相似文献

1
A high-resolution linkage map of the tight skin 2 (Tsk2) locus: a mouse model for scleroderma (SSc) and other cutaneous fibrotic diseases.紧密皮肤2（Tsk2）位点的高分辨率连锁图谱：硬皮病（SSc）和其他皮肤纤维化疾病的小鼠模型。
Mamm Genome. 1996 Aug;7(8):610-2. doi: 10.1007/s003359900181.
2
The tight skin 2 mouse. An animal model of scleroderma displaying cutaneous fibrosis and mononuclear cell infiltration.紧皮2小鼠。一种显示皮肤纤维化和单核细胞浸润的硬皮病动物模型。
Arthritis Rheum. 1995 Dec;38(12):1791-8. doi: 10.1002/art.1780381212.
3
The tight skin (Tsk) mutation in the mouse, a model for human fibrotic diseases, is tightly linked to the beta 2-microglobulin (B2m) gene on chromosome 2.
Genomics. 1993 Sep;17(3):748-51. doi: 10.1006/geno.1993.1398.
4
The Tsk2/+ mouse fibrotic phenotype is due to a gain-of-function mutation in the PIIINP segment of the Col3a1 gene.Tsk2/+小鼠的纤维化表型是由于Col3a1基因的PIIINP区段发生功能获得性突变所致。
J Invest Dermatol. 2015 Mar;135(3):718-27. doi: 10.1038/jid.2014.455. Epub 2014 Oct 20.
5
Location of plucked (pk) on chromosome 18 of the mouse.
J Hered. 1985 Nov-Dec;76(6):476-7. doi: 10.1093/oxfordjournals.jhered.a110152.
6
Tight-skin (Tsk) maps on mouse chromosome 2 within the region of linkage homology with human chromosome 15.紧皮（Tsk）基因定位于小鼠2号染色体上，与人类15号染色体存在连锁同源区域。
Genomics. 1994 Jul 1;22(1):223-5. doi: 10.1006/geno.1994.1368.
7
The fld mutation maps near to but distinct from the Apob locus on mouse chromosome 12.fld突变定位于小鼠12号染色体上靠近载脂蛋白B（Apob）基因座但与之不同的位置。
Mamm Genome. 1996 Jul;7(7):555-7. doi: 10.1007/s003359900166.
8
Genetic mapping of the mouse neuromuscular mutation kyphoscoliosis.
Genomics. 1995 Jan 1;25(1):207-13. doi: 10.1016/0888-7543(95)80127-8.
9
Effect of the mouse scid mutation on meiotic recombination.
Mamm Genome. 1996 Jul;7(7):497-500. doi: 10.1007/s003359900150.
10
Mapping of the azh locus to mouse chromosome 4.将azh基因座定位到小鼠4号染色体上。
J Hered. 1992 Jan-Feb;83(1):56-61. doi: 10.1093/oxfordjournals.jhered.a111157.

引用本文的文献

1
Animal models of systemic sclerosis: their utility and limitations.系统性硬化症的动物模型：其效用与局限性
Open Access Rheumatol. 2014 Jul 1;6:65-81. doi: 10.2147/OARRR.S50009. eCollection 2014.
2
Identification of Optimal Mouse Models of Systemic Sclerosis by Interspecies Comparative Genomics.通过种间比较基因组学鉴定系统性硬化症的最佳小鼠模型。
Arthritis Rheumatol. 2016 Aug;68(8):2003-15. doi: 10.1002/art.39658.
3
The Tsk2/+ mouse fibrotic phenotype is due to a gain-of-function mutation in the PIIINP segment of the Col3a1 gene.

本文引用的文献

1
The tight skin 2 mouse. An animal model of scleroderma displaying cutaneous fibrosis and mononuclear cell infiltration.紧皮2小鼠。一种显示皮肤纤维化和单核细胞浸润的硬皮病动物模型。
Arthritis Rheum. 1995 Dec;38(12):1791-8. doi: 10.1002/art.1780381212.
2
High-resolution linkage map in the vicinity of the host resistance locus Bcg.宿主抗性基因座Bcg附近的高分辨率连锁图谱。
Genomics. 1993 Jun;16(3):655-63. doi: 10.1006/geno.1993.1244.
3
The tight skin (Tsk) mutation in the mouse, a model for human fibrotic diseases, is tightly linked to the beta 2-microglobulin (B2m) gene on chromosome 2.
Tsk2/+小鼠的纤维化表型是由于Col3a1基因的PIIINP区段发生功能获得性突变所致。
J Invest Dermatol. 2015 Mar;135(3):718-27. doi: 10.1038/jid.2014.455. Epub 2014 Oct 20.
4
Collagen content in skin and internal organs of the tight skin mouse: an animal model of scleroderma.紧皮小鼠皮肤和内脏器官中的胶原蛋白含量：硬皮病动物模型
Biochem Res Int. 2013;2013:436053. doi: 10.1155/2013/436053. Epub 2013 Oct 24.
5
Animal models in scleroderma.硬皮病的动物模型
Curr Rheumatol Rep. 2005 Apr;7(2):150-5. doi: 10.1007/s11926-005-0068-x.
6
Genetic and immunologic features associated with scleroderma-like syndrome of TSK mice.与TSK小鼠硬皮病样综合征相关的遗传和免疫学特征。
Curr Rheumatol Rep. 1999 Oct;1(1):34-7. doi: 10.1007/s11926-999-0022-4.
Genomics. 1993 Sep;17(3):748-51. doi: 10.1006/geno.1993.1398.
4
Coordinate regulation of the levels of type III and type I collagen mRNA in most but not all mouse fibroblasts.大多数（但并非所有）小鼠成纤维细胞中III型和I型胶原蛋白mRNA水平的协调调节。
J Biol Chem. 1985 Jan 10;260(1):531-6.
5
Recombinant inbred strain and interspecific backcross analysis of molecular markers flanking the murine agouti coat color locus.小鼠刺豚鼠毛色位点侧翼分子标记的重组近交系和种间回交分析。
Genetics. 1989 Jul;122(3):669-79. doi: 10.1093/genetics/122.3.669.
6
Fibronectin gene expression in proliferating, quiescent, and SV40-infected mouse kidney cells.纤连蛋白基因在增殖、静止及SV40感染的小鼠肾细胞中的表达。
Exp Cell Res. 1992 Oct;202(2):464-70. doi: 10.1016/0014-4827(92)90100-m.
7
Tight-skin, a new mutation of the mouse causing excessive growth of connective tissue and skeleton.紧皮小鼠，一种导致结缔组织和骨骼过度生长的小鼠新突变体。
Am J Pathol. 1976 Mar;82(3):493-512.