金属离子诱导的自身免疫

Metal ion induced autoimmunity.

作者信息

Griem P, Gleichmann E

机构信息

Medical Institute of Environmental Hygiene at Heinrich Heine University, Düsseldorf, Germany.

出版信息

Curr Opin Immunol. 1995 Dec;7(6):831-8. doi: 10.1016/0952-7915(95)80056-5.

DOI:10.1016/0952-7915(95)80056-5

PMID:8679128

Abstract

Metal-induced autoimmunity is a well established but poorly understood phenomenon. Recent work has begun to elucidate the molecular interactions of metal ions with immune cells and self-proteins. Metal-induced presentation of cryptic self-peptides emerges as a possible mechanism for activation of 'metal-specific' T cells, challenging the hypothesis of a random polyclonal activation of T and B cells by metals. A preferential T-helper cell type 2 response is involved in metal ion induced systemic autoimmune disease.

摘要

金属诱导的自身免疫是一种已被充分证实但了解甚少的现象。最近的研究工作已开始阐明金属离子与免疫细胞及自身蛋白之间的分子相互作用。金属诱导的隐蔽自身肽的呈递成为激活“金属特异性”T细胞的一种可能机制，这对金属随机多克隆激活T细胞和B细胞的假说提出了挑战。2型辅助性T细胞优先反应参与金属离子诱导的系统性自身免疫疾病。