Kaibara M
Institute of Physical and Chemical Research, Wako, Japan.
Biorheology. 1996 Mar-Apr;33(2):101-17. doi: 10.1016/0006-355X(96)00010-8.
There have been a number of investigations on coagulation reactions of blood as well as on coagulation factors including fibrinogen and thrombin. With the progress of clotting, the viscosity and rigidity of blood increase, facts related to the clot structure of fibrin. Therefore, rheological measurements make it possible to investigate the process of blood clotting as well as the properties of the fibrin clot. In this paper, our rheological studies on blood coagulation are summarized. The network structure of fibrin clots formed under different conditions is discussed from the kinetic analysis of the change of dynamic rigidity modulus during clotting. Also it will be shown that rheological techniques make it possible to analyze the initial coagulation reaction of blood in contact with components constituting the vascular vessel. The analysis indicates that a coagulation factor in plasma is activated on the erythrocyte surface.
针对血液的凝血反应以及包括纤维蛋白原和凝血酶在内的凝血因子，已经开展了大量研究。随着凝血过程的推进，血液的黏度和硬度会增加，这些事实与纤维蛋白的凝块结构相关。因此，流变学测量使得研究血液凝固过程以及纤维蛋白凝块的特性成为可能。在本文中，我们对血液凝固的流变学研究进行了总结。通过对凝血过程中动态刚性模量变化的动力学分析，讨论了在不同条件下形成的纤维蛋白凝块的网络结构。此外，还将表明流变学技术能够分析血液与构成血管的成分接触时的初始凝血反应。分析表明，血浆中的一种凝血因子在红细胞表面被激活。
