Hecquet B
Laboratoire de pharmacodynamie clinique, centre Oscar-Lambret, Lille, France.
Bull Cancer. 1995 Dec;82 Suppl 5:607s-611s.
A major objective for pharmacokineticians is to help practicians to define drug administration protocols. Protocols are generally designed for all the patients but inter individual variability would need monitoring for each patient. Computers are widely used to determine pharmacokinetic parameters and to try to individualize drug administration. Severals examples are summarily described: terminal half-life determination by regression; model fitting to experimental data; Bayesian statistics for individual dose adaptation; population pharmacokinetic methods for parameter evaluation. These methods do not replace the pharmacokinetician thought but could make possible drug administration taking into account individual characteristics.
药代动力学家的一个主要目标是帮助从业者确定给药方案。给药方案通常是为所有患者设计的，但个体间的差异需要对每个患者进行监测。计算机被广泛用于确定药代动力学参数，并试图实现个体化给药。简要描述了几个例子：通过回归确定终末半衰期；将模型拟合到实验数据；用于个体剂量调整的贝叶斯统计；用于参数评估的群体药代动力学方法。这些方法并不能取代药代动力学家的思考，但可以在考虑个体特征的情况下实现给药。
