Kaburaki J, Kuwana M, Yamamoto M, Kawai S, Matsuura E, Ikeda Y
Department of Internal Medicine, Keio University School of Medicine, Tokyo.
Intern Med. 1996 Feb;35(2):105-10. doi: 10.2169/internalmedicine.35.105.
A portion of anticardiolipin antibodies is defined as phospholipid-dependent anti-beta 2-glycoprotein I (beta 2-GPI) antibodies and recognizes the conformationally altered beta 2 GPI which interacts with anionic phospholipids. We studied the clinical significance of IgG phospholipid-dependent anti-beta 2-GPI antibodies in patients with antiphospholipid syndrome (APS). The subjects consisted of 60 APS patients. IgG phospholipid-dependent anti-beta 2-GPI antibodies were detected by ELISA in 32 of the 60 patients (53%). Significantly higher incidences of prolonged APTT and lupus anticoagulants were found in patients with these anti-beta 2-GPI antibodies. Moreover, significantly lower incidences of malar rash, serositis, LE cell preparation and anti-Sm antibodies were found in patients with these anti-beta 2-GPI antibodies. It was found that 88% of the patients with these anti-beta 2-GPI antibodies satisfied less than five of the revised criteria items for the classification of SLE. These findings indicate the clinical characteristics of APS patients with IgG phospholipid-dependent anti-beta 2-GPI antibodies.
一部分抗心磷脂抗体被定义为磷脂依赖性抗β2糖蛋白I（β2-GPI）抗体，可识别与阴离子磷脂相互作用的构象改变的β2-GPI。我们研究了抗磷脂综合征（APS）患者中IgG磷脂依赖性抗β2-GPI抗体的临床意义。研究对象包括60例APS患者。通过ELISA在60例患者中的32例（53%）检测到IgG磷脂依赖性抗β2-GPI抗体。在这些抗β2-GPI抗体阳性的患者中，活化部分凝血活酶时间（APTT）延长和狼疮抗凝物的发生率显著更高。此外，在这些抗β2-GPI抗体阳性的患者中，颧部红斑、浆膜炎、狼疮细胞检查及抗Sm抗体的发生率显著更低。发现这些抗β2-GPI抗体阳性的患者中88%符合系统性红斑狼疮（SLE）分类修订标准项目少于五项。这些发现表明了具有IgG磷脂依赖性抗β2-GPI抗体的APS患者的临床特征。
