Kitagawa Y, Nimura Y, Kanda H, Uematsu T, Kamiya S, Machiki Y, Watanabe T
First Department of Surgery, Nagoya University School of Medicine, Japan.
Surg Today. 1996;26(1):21-8. doi: 10.1007/BF00311987.
This study was conducted to examine how the effects of dopamine and dobutamine on hepatic blood flow were influenced by obstructive jaundice in a conscious canine model. Prior to biliary obstruction, portal venous blood flow (PVF) increased in response to the infusion of either dopamine or dobutamine: dopamine infused at 8 micrograms/kg per min produced an increase of 19 +/- 0% in PVF, while dobutamine infused at 16 micrograms/kg per min produced an increase of 30 +/- 2%. Although hepatic arterial blood flow (HAF) decreased dose-dependently in response to the infusion of dopamine, no significant change was observed in HAF in response to any dose of dobutamine. Obstructive jaundice attenuated or completely abolished the PVF-increasing effect of dopamine, whereas it did not significantly alter the effect of dobutamine on hepatic blood flow. In dogs with obstructive jaundice, dopamine at 16 micrograms/kg per min produced a decrease of 17 +/- 3% in PVF. These findings suggest that dobutamine is more effective than dopamine for increasing hepatic blood flow in patients with obstructive jaundice.
本研究旨在探讨在清醒犬模型中，梗阻性黄疸如何影响多巴胺和多巴酚丁胺对肝血流量的作用。在胆道梗阻前，门静脉血流量（PVF）对多巴胺或多巴酚丁胺输注有反应而增加：以每分钟8微克/千克的速度输注多巴胺使PVF增加19±0%，而以每分钟16微克/千克的速度输注多巴酚丁胺使PVF增加30±2%。尽管肝动脉血流量（HAF）对多巴胺输注呈剂量依赖性下降，但对任何剂量的多巴酚丁胺输注，HAF均未观察到显著变化。梗阻性黄疸减弱或完全消除了多巴胺增加PVF的作用，而对多巴酚丁胺对肝血流量的作用无显著改变。在患有梗阻性黄疸的犬中，以每分钟16微克/千克的速度输注多巴胺使PVF下降17±3%。这些发现表明，在梗阻性黄疸患者中，多巴酚丁胺在增加肝血流量方面比多巴胺更有效。
