Michel M, Dompmartin A, Szczurko C, Castel B, Moreau A, Leroy D
Service de Dermatologie Centre Hospitalier Universitaire, Caen, France.
Contact Dermatitis. 1996 Feb;34(2):86-7. doi: 10.1111/j.1600-0536.1996.tb02135.x.
The authors report 4 cases of eczematous-like drug eruption after oral ingestion of synergistins, pristinamycin (3 cases) and virginiamycin (1 case). The lesions occurred after contact sensitization with topical virginiamycin. The clinical symptoms appeared a few hours after ingestion: a generalized maculopapular eruption, sometimes with general symptoms of anaphylactic reaction. Eczema appeared again on initial areas of contact dermatitis. There is a common allergenic group between these 2 antibiotics, which is a macrocyclic lactone. Physiopathology of this drug eruption is not clear: allergic reaction of the delayed type or anaphylactic reaction. Patients allergic to virginiamycin should be strongly cautioned against oral pristinamycin.
作者报告了4例口服增效菌素、 pristinamycin（3例）和维吉尼亚霉素（1例）后出现的类湿疹样药疹。这些皮疹是在局部使用维吉尼亚霉素引起接触致敏后出现的。临床症状在服药后数小时出现：全身性斑丘疹，有时伴有过敏反应的全身症状。在最初的接触性皮炎部位再次出现湿疹。这两种抗生素之间存在一个共同的过敏原组，即大环内酯类。这种药疹的病理生理学尚不清楚：是迟发型过敏反应还是过敏反应。对维吉尼亚霉素过敏的患者应强烈警告不要口服pristinamycin。
