Halerz-Nowakowska B
Kliniki Endokrynologii Ginekologicznej, Instytutu Ginekologii i Połoznictwa AM w Poznaniu.
Ginekol Pol. 1995 Oct;66(10):553-60.
The main goal of this study was to measure changes in pituitary and sex hormone levels as a result of surgical or natural menopause, assess influences and correlation's between concentration of hormones and selected parameters of lipid profile important in the atherogenesis in the early period after surgical ovariectomy and during natural menopause. The first group consisted of 59 women (age +/- 3, 7) on whom hysterectomy with bilateral ovariectomy were performed. Blood samples were taken before operation and on 9th day after the operation. The second group consisted of 28 postmenopausal women (age 53 +/- 4). Methods hormonal measures were performed by radioimmunometric assays in blood serum (FSH, LH, PRL, 17-beta estradiol, testosterone, androstenedione and SHGB). The assessment of particular parameters of lipid profile: total cholesterol, HDL-C, LDL-C and triglycerides was performed by biochemical methods.
We found statistically important, negative correlation between levels of estradiol and gonadotrophins; after surgical ovariectomy and natural menopause there are time depended changes in lipid profile. Early period after surgical ovariectomy is characterized by decrease in concentration of 17-beta estradiol and increase of atherogenic lipid parameters. Among postmenopausal women there is negative correlation between 17-beta estradiol concentration and atherogenic factor and total cholesterol. Changes of the lipid profile in the serum of the blood may be connected with hormonal homeostatic disturbances, decreased level of oestrogen's and rising level of gonadotrophins.
本研究的主要目的是测量手术绝经或自然绝经导致的垂体和性激素水平变化，评估手术去卵巢术后早期及自然绝经期间激素浓度与动脉粥样硬化形成中重要的血脂谱选定参数之间的影响和相关性。第一组由59名女性组成（年龄±3.7岁），她们接受了子宫切除术及双侧卵巢切除术。术前及术后第9天采集血样。第二组由28名绝经后女性组成（年龄53±4岁）。采用放射免疫分析法测定血清中的激素水平（促卵泡生成素、促黄体生成素、催乳素、17-β雌二醇、睾酮、雄烯二酮和性激素结合球蛋白）。采用生化方法评估血脂谱的特定参数：总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和甘油三酯。
我们发现雌二醇水平与促性腺激素之间存在统计学上的显著负相关；手术去卵巢术后及自然绝经后血脂谱存在时间依赖性变化。手术去卵巢术后早期的特征是17-β雌二醇浓度降低和动脉粥样硬化性脂质参数增加。在绝经后女性中，17-β雌二醇浓度与动脉粥样硬化因子及总胆固醇之间存在负相关。血液血清中血脂谱的变化可能与激素稳态紊乱、雌激素水平降低和促性腺激素水平升高有关。
