Andresen D
Abteilung für Innere Medizin mit Schwerpunkt Kardiologie und Pulmologie, Freien Universität Berlin.
Fortschr Med. 1996 Apr 20;114(11):128-32.
Ten to twenty percent of the patients, who were resuscitated as a result of a persistent ventricular tachycardia or ventricular fibrillation outside of an acute myocardial infarction, die of sudden cardiac death already in the first year after this event. Anti-arrhythmic agents also do not decisively improve this unfavorable prognosis. There is no doubt that the implantable cardioverter/defibrillator (ICD) safely and reliably terminates ventricular tachycardias and ventricular fibrillation and has thus led to an improvement in the care of these high risk patients. Studies have shown that the ICD reduces the risk of sudden cardiac death to 1-2% per year. However, whether the reduction of sudden cardiac death is also accompanied by a reduction in overall mortality has not yet been substantiated. It was, however, been assumed that especially patients with good left ventricular function, whose mortality risk is mainly sudden cardiac death, also profit from the overall prognosis of an ICD. The following presentation and discussion of the indication catalogue for the implantation of defibrillators is based on a guideline paper published by the study group "Interventional Electrophysiology" in the German Society for Cardiology. The statements clearly show how difficult it is to make long-term binding and valid recommendations due to insufficient scientific data and rapid technical development. Identifying patients who should be treated with an ICD requires complete noninvasive and invasive cardiological diagnostics and should ultimately be limited to cardiological centers which possess a large arsenal of diagnostic and therapeutic procedures.
在急性心肌梗死之外因持续性室性心动过速或心室颤动而复苏的患者中,有10%至20%在该事件后的第一年就死于心源性猝死。抗心律失常药物也不能决定性地改善这种不良预后。毫无疑问,植入式心脏复律除颤器(ICD)能安全可靠地终止室性心动过速和心室颤动,从而改善了对这些高危患者的治疗。研究表明,ICD将心源性猝死的风险降低至每年1%至2%。然而,心源性猝死的降低是否也伴随着总死亡率的降低尚未得到证实。不过,人们认为,尤其是左心室功能良好、死亡风险主要是心源性猝死的患者,也能从ICD的总体预后中获益。以下关于除颤器植入适应证目录的介绍和讨论基于德国心脏病学会“介入电生理学”研究小组发表的一篇指南文件。这些陈述清楚地表明,由于科学数据不足和技术快速发展,做出长期有约束力且有效的建议是多么困难。确定哪些患者应接受ICD治疗需要完整的非侵入性和侵入性心脏诊断,最终应限于拥有大量诊断和治疗手段的心脏病中心。