Shannon E J, Sandoval F
Gillis W. Long Hansen's Disease Center, Louisiana State University, Baton Rouge, USA.
Immunopharmacol Immunotoxicol. 1996 Feb;18(1):59-72. doi: 10.3109/08923979609007110.
The effect if thalidomide on tumor necrosis factor alpha (TNF-alpha) produced in vitro by lipopolysaccharide (LPS) stimulated human cells was investigated. In cultures of LPS stimulated human mononuclear cells enriched for adherent cells and in cultures of LPS stimulated human monocytes of the cell line-THP-1, thalidomide enhanced the synthesis of TNF-alpha. When cultures of unfractionated peripheral blood mononuclear cells were stimulated with LPS, thalidomide decreased the synthesis of TNF-alpha. Depending on the type of cells stimulated with LPS in vitro, thalidomide, at concentrations achieved in vivo, can either enhance or suppress the synthesis of TNF-alpha.
研究了沙利度胺对脂多糖（LPS）刺激的人细胞体外产生肿瘤坏死因子α（TNF-α）的影响。在富含贴壁细胞的LPS刺激的人单核细胞培养物以及LPS刺激的细胞系THP-1的人单核细胞培养物中，沙利度胺增强了TNF-α的合成。当用LPS刺激未分级的外周血单核细胞培养物时，沙利度胺降低了TNF-α的合成。根据体外受LPS刺激的细胞类型，沙利度胺在体内达到的浓度下可增强或抑制TNF-α的合成。
