McLarney M J, Pellett P L, Young V R
Department of Nutrition, University of Massachusetts, Amherst 01003, USA.
J Nutr. 1996 Jul;126(7):1871-82. doi: 10.1093/jn/126.7.1871.
We undertook an interspecies comparison of essential (indispensable) amino acid requirements, in relation to those for total protein, to examine whether the current, internationally proposed human amino acid requirement patterns are significantly different from those of other animals. Data were compiled in their original form and then expressed as mg amino acid/g total dietary protein (N X 6.25) required (amino acid requirement pattern). Patterns of requirements within the various species were organized according to four, arbitrary age-developmental groupings (very young, early growth, growth and mature), and these were compared with the requirements for (a) human infants, (b) 2-5 year old children, (c) 10-12 year old children and (c) adults, respectively. Statistical comparisons determined if significant differences existed between humans and other species, at apparently similar age-development stages, for both the total and for individual indispensable amino acids. The sum of the specific indispensable amino acid requirements for humans was significantly different than that for other species at infancy, growth and adulthood; the greatest differences, however, were for the amino acid requirement pattern in adulthood. The change between the very young and adult was the greatest for humans. Some of this difference might be due to experimental factors, including the biological status of a species within the arbitrary groupings described and the criteria used to determine "requirements." Nevertheless, it is difficult to escape the conclusion that the current international human amino acid requirements, for adults in particular, appear to be anomalous when judged against data for other animal species.
我们对必需（不可或缺）氨基酸需求进行了种间比较，将其与总蛋白质需求相关联，以研究当前国际上提出的人类氨基酸需求模式是否与其他动物的模式存在显著差异。数据以原始形式汇编，然后表示为每克总膳食蛋白质（氮×6.25）所需的氨基酸毫克数（氨基酸需求模式）。各种物种内的需求模式根据四个任意的年龄发育分组（极幼龄、生长早期、生长阶段和成年期）进行整理，并分别与（a）人类婴儿、（b）2 - 5岁儿童、（c）10 - 12岁儿童和（d）成年人的需求进行比较。统计比较确定了在明显相似的年龄发育阶段，人类与其他物种在总必需氨基酸和单个必需氨基酸方面是否存在显著差异。人类特定必需氨基酸需求的总和在婴儿期、生长阶段和成年期与其他物种存在显著差异；然而，最大的差异在于成年期的氨基酸需求模式。人类从极幼龄到成年的变化最大。这种差异部分可能归因于实验因素，包括在所述任意分组内物种的生物学状态以及用于确定“需求”的标准。然而，很难避免这样的结论：与其他动物物种的数据相比，当前国际上的人类氨基酸需求，特别是成年人的需求，似乎是异常的。
