Liu T C, Irish J C, Adams S G, Durkin L C, Hunt E J
Department of Otolaryngology, University of Toronto Faculty of Medicine, Ontario.
J Otolaryngol. 1996 Apr;25(2):66-74.
Adductor spasmodic dysphonia (SD) is a speech disorder resulting from involuntary contractions of the laryngeal muscles. Botulinum toxin (BT) injection of the thyroarytenoid muscle is an effective, though temporary, treatment for most SD patients. Though there are reports of objective improvements in voice quality, there are no large studies of patients' subjective responses to treatment over time. In the present study, patients were given voice diaries to rate vocal spasms, hoarseness, breathiness, volume problems, and dysphagia before and the after treatment. Analysis of these diaries revealed that: (1) most side effects had resolved 4 to 6 weeks after injection, whereas vocal spasm relief persisted; (2) vocal spasm relief and severity of side effects peaked within 1 week; and (3) unilateral injections, though as effective in relieving vocal spasms, caused less volume and swallowing problems than did bilateral injections.
内收型痉挛性发声障碍（SD）是一种由喉部肌肉不自主收缩导致的言语障碍。对大多数SD患者而言，向甲杓肌注射肉毒杆菌毒素（BT）是一种有效的治疗方法，尽管只是暂时有效。虽然有报告称嗓音质量有客观改善，但尚无关于患者对治疗的主观反应随时间变化的大型研究。在本研究中，患者在治疗前后使用嗓音日记对声带痉挛、声音嘶哑、呼吸音、音量问题和吞咽困难进行评分。对这些日记的分析显示：（1）大多数副作用在注射后4至6周内消失，而声带痉挛缓解持续存在；（2）声带痉挛缓解和副作用严重程度在1周内达到峰值；（3）单侧注射虽然在缓解声带痉挛方面同样有效，但比双侧注射引起的音量和吞咽问题更少。
