Levesque P E, Bauer S B, Atala A, Zurakowski D, Colodny A, Peters C, Retik A B
Division of Urology, Children's Hospital, Boston, Massachusetts, USA.
J Urol. 1996 Aug;156(2 Pt 2):625-8. doi: 10.1097/00005392-199608001-00014.
To assess the efficacy of the artificial urinary sphincter survival and continence were first evaluated 5 years ago. We now evaluated the effects of the artificial urinary sphincter more than a decade after implantation.
Before 1985 an artificial urinary sphincter was implanted in 22 male and 14 female consecutive patients 4 to 30 years old (median age 12). In addition, between 1985 and 1990, 18 other children underwent artificial urinary sphincter implantation. Results of both series were compared.
Of the 25 sphincters in the original series that were functioning after 5 years 1 was removed and 2 patients were lost to followup, resulting in 22 functioning implants (61% of the patients). Mean survival time of the prostheses was 12.1 years and average followup for functioning sphincters was 13.7 years. There was no statistically significant difference in artificial urinary sphincter survival between the original group at 5 years and the second group treated after 1985. Of the patients in both groups with sphincters in place 32 of 39 (82%) were dry. Augmentation cystoplasty was performed in 9 of 18 patients (50%) in the second series (5 preoperatively and 4 postoperatively) compared to 10 of 36 (28%) in the original series at 5 years (3 preoperatively and 7 postoperatively). Renal failure developed in 6 patients from both series.
The artificial urinary sphincter is a durable long-term solution for children with intractable incontinence. Long-term surveillance of the urinary tract is mandatory because of the potential for renal failure in patients who have bladder hypertonicity after placement of the device.
人工尿道括约肌的疗效评估中,5年前首次对其存活情况及控尿能力进行了评估。我们现在对人工尿道括约肌植入十多年后的效果进行评估。
1985年前,连续22例男性和14例女性4至30岁(中位年龄12岁)患者植入了人工尿道括约肌。此外,1985年至1990年间,另有18名儿童接受了人工尿道括约肌植入。对这两个系列的结果进行了比较。
在最初系列中,25个5年后仍在发挥功能的括约肌中,1个被移除,2例患者失访,最终有22个植入物仍在发挥功能(占患者的61%)。假体的平均存活时间为12.1年,对仍在发挥功能的括约肌的平均随访时间为13.7年。5年时最初组与1985年后治疗的第二组在人工尿道括约肌存活方面无统计学显著差异。在两组括约肌在位的患者中,39例中有32例(82%)无尿失禁。第二系列中18例患者中有9例(50%)进行了膀胱扩大术(5例术前,4例术后),而最初系列5年时36例中有10例(28%)进行了膀胱扩大术(3例术前,7例术后)。两个系列均有6例患者出现肾衰竭。
人工尿道括约肌是治疗顽固性尿失禁儿童的一种持久的长期解决方案。由于植入该装置后膀胱张力过高的患者有发生肾衰竭的可能,因此对尿路进行长期监测是必要的。