Husmann D A, Milliner D S, Segura J W
Department of Urology, Mayo Clinic, Rochester, Minnesota 55905, USA.
J Urol. 1996 Aug;156(2 Pt 2):741-3. doi: 10.1097/00005392-199608001-00049.
We determined the long-term prognosis of the pediatric patient presenting with simultaneous ureteropelvic junction obstruction and a renal calculus.
We retrospectively reviewed all individuals younger than 17 years who presented to our institutions with simultaneous ureteropelvic junction obstruction and an ipsilateral renal calculus.
Simultaneous ureteropelvic junction obstruction with nonstruvite calculi was present in 22 patients, while 6 had struvite calculi. Median age at diagnosis was 11 years (range 5 to 16). During a median followup of 9 years (range 2 to 38) renal calculi recurred in 19 patients (68%), including 10 (36%) with 1 and 9 (32%) with 2 or more recurrences. Median time to first stone recurrence was 11 years (range 2 to 38). Of the 22 patients with nonstruvite calculi 15 (68%) had recurrence. An identifiable metabolic etiology for renal lithiasis was found in 13 of these patients (87%). In contrast, only 2 of the 7 patients (29%) with nonstruvite calculi and no recurrent stones had an identifiable abnormality. This finding suggests that the presence of an identifiable metabolic abnormality significantly predisposes to recurrent nonstruvite renal lithiasis (p < 0.01).
Of the pediatric patients presenting with simultaneous ureteropelvic junction obstruction and a renal calculus 68% will have recurrent renal lithiasis. It remains to be determined whether active treatment of coexisting metabolic abnormalities could prevent or reduce the incidence of recurrent stone disease.
我们确定了同时患有输尿管肾盂连接部梗阻和肾结石的儿科患者的长期预后。
我们回顾性分析了所有17岁以下同时患有输尿管肾盂连接部梗阻和同侧肾结石并就诊于我们机构的患者。
22例患者存在同时性输尿管肾盂连接部梗阻合并非鸟粪石结石,6例存在鸟粪石结石。诊断时的中位年龄为11岁(范围5至16岁)。在中位随访9年(范围2至38年)期间,19例患者(68%)出现肾结石复发,其中10例(36%)复发1次,9例(32%)复发2次或更多次。首次结石复发的中位时间为11年(范围2至38年)。在22例非鸟粪石结石患者中,15例(68%)复发。其中13例患者(87%)发现了可识别的肾结石代谢病因。相比之下,7例非鸟粪石结石且无结石复发的患者中只有2例(29%)存在可识别的异常。这一发现表明,存在可识别的代谢异常显著增加了非鸟粪石性复发性肾结石的易感性(p<0.01)。
在同时患有输尿管肾盂连接部梗阻和肾结石的儿科患者中,68%会出现复发性肾结石。共存的代谢异常的积极治疗是否能预防或降低复发性结石病的发生率仍有待确定。