Konovalov G V, Chumasov E I, Fedorova L A
Zh Nevropatol Psikhiatr Im S S Korsakova. 1977;77(4):503-8.
The perineurium performs the role of a diffuse neurotissue barrier, protecting the nervous fibres from extra neuronal pathological processes. The changes in the cellular layers of the perineurium in experimental allergic polyneuritis appear secondarily and are directly connected with the severity and localization of the demyelinating process. As a result of a developing demyelinization in the foci of allergic inflammation there is an accumulation of biologically active substances which lead to disturbances of permeability and the intactness of cellular layers of the perineurium. In its turn this leads to the proliferation of a protein exudate from the endobeurium into its intracellular spaces. The dystrophic changes were in the form of large vacuoles, spaces, lacunes of an incorrect form filled with proteins and a large amount of lysosome-like bodies. The cell nuclei were subjected to pycnosis and perinuclear swelling. In the other 3-5 layers there were only processes of a reactive character: a swelling of the cytoplasma, an enlargement of the cysterns in the endoplasmatic reticulum, an increase of the amount of free ribosomes and pynocytic vesicles.
神经束膜起着弥散性神经组织屏障的作用，保护神经纤维免受神经元外病理过程的影响。实验性变应性多神经炎中神经束膜细胞层的变化是继发性的，且与脱髓鞘过程的严重程度和部位直接相关。由于变应性炎症病灶中脱髓鞘的发展，生物活性物质积聚，导致神经束膜细胞层通透性和完整性受到干扰。这进而导致蛋白渗出物从神经内膜增殖到其细胞内间隙。营养不良性变化表现为大空泡、间隙、形状不规则的腔隙，充满蛋白质和大量溶酶体样小体。细胞核出现核固缩和核周肿胀。在其他3 - 5层中，只有反应性变化：细胞质肿胀、内质网中潴泡扩大、游离核糖体和吞噬泡数量增加。
