性类固醇激素与巨噬细胞功能。

Sex steroid hormones and macrophage function.

作者信息

Miller L, Hunt J S

机构信息

Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City 66160, USA.

出版信息

Life Sci. 1996;59(1):1-14. doi: 10.1016/0024-3205(96)00122-1.

DOI:10.1016/0024-3205(96)00122-1

PMID:8684265

Abstract

Macrophages are versatile cells whose activities are programmed by environmental signals. In this review, we discuss the potential impact of sex steroid hormones on macrophage activation and production of various effector molecules. The evidence accumulated to date supports the postulate that estrogens, progesterone, androgens and testosterone profoundly influence host defense by controlling the ability of macrophages to participate in immune responses.

摘要

巨噬细胞是一种多功能细胞，其活动由环境信号编程。在本综述中，我们讨论了性甾体激素对巨噬细胞活化和各种效应分子产生的潜在影响。迄今为止积累的证据支持这样一种假设，即雌激素、孕酮、雄激素和睾酮通过控制巨噬细胞参与免疫反应的能力，对宿主防御产生深远影响。