Zampi G, Comin C E, Dini S
Institute of Pathological Anatomy and Histology, University of Florence, Italy.
Med Lav. 1995 Sep-Oct;86(5):389-92.
Malignant mesothelioma is an uncommon tumour, which has become an important epidemiological marker for exposure to asbestos. This tumour is characterised by a wide range of microscopic features which may be classified in three histologic patterns: epithelial, mesenchimal and mixed or biphasic. Histochemical staining is often necessary to distinguish mesothelioma from carcinoma. As regards immunohistochemistry, only the use of a combination of antibodies significantly decreases the risk of false-negative results. Analytic electron microscopy techniques may also be useful, permitting the evaluation of the cumulative fiber burden in the target organ.
恶性间皮瘤是一种罕见的肿瘤，已成为接触石棉的重要流行病学标志物。这种肿瘤具有多种微观特征，可分为三种组织学类型：上皮型、间充质型和混合型或双相型。通常需要进行组织化学染色以将间皮瘤与癌区分开来。关于免疫组织化学，只有联合使用抗体才能显著降低假阴性结果的风险。分析电子显微镜技术也可能有用，可用于评估靶器官中的累积纤维负荷。
