Wagner N, Löhler J, Kunkel E J, Ley K, Leung E, Krissansen G, Rajewsky K, Müller W
Institute for Genetics, University of Cologne, Germany.
Nature. 1996 Jul 25;382(6589):366-70. doi: 10.1038/382366a0.
Immune defence against pathogens entering the gut is accomplished by lymphocytes in the gut-associated lymphoid tissue (GALT), a major compartment of the immune system. The GALT, comprising Peyer's patches, lamina propria lymphocytes and intra-epithelial lymphocytes of the intestine, is populated by lymphocytes that migrate there from the vasculature. Here we report that, in mice deficient for the beta7 integrin subfamily of adhesion molecules, the formation of the GALT is severely impaired. This is probably due to a failure of beta7-/- lymphocytes to arrest and adhere to the vasculature at the site of transmigration into the GALT.
肠道相关淋巴组织（GALT）是免疫系统的一个主要组成部分，对进入肠道的病原体的免疫防御是由该组织中的淋巴细胞完成的。GALT由派尔集合淋巴结、固有层淋巴细胞和肠道上皮内淋巴细胞组成，其中的淋巴细胞是从脉管系统迁移而来的。我们在此报告，在缺乏黏附分子β7整合素亚家族的小鼠中，GALT的形成严重受损。这可能是由于β7基因敲除的淋巴细胞在迁移进入GALT的部位无法在脉管系统处停滞并黏附。
