Kitzmiller J L, Combs C A
Division of Maternal-Fetal Medicine, Good Samaritan Health System, San Jose, California, USA.
Obstet Gynecol Clin North Am. 1996 Mar;23(1):173-203. doi: 10.1016/s0889-8545(05)70251-5.
Knowledge of the pathogenic mechanisms of diabetic nephropathy (by which hyperglycemia, hyperfiltration, and hypertension cause the gradual development of microproteinuria, mesangial expansion, and eventual glomerular closure) provides the basis for effective treatment. Intensified glycemic control and antihypertensive therapy that is safe for the fetus are crucial for success during pregnancy. Considered outcome measures include perinatal survival, size at birth, child development, and long-term maternal renal function.
了解糖尿病肾病的致病机制（高血糖、高滤过和高血压如何导致微量蛋白尿、系膜扩张并最终导致肾小球闭锁的逐渐发展）为有效治疗提供了依据。强化血糖控制以及对胎儿安全的抗高血压治疗对孕期成功至关重要。考虑的结局指标包括围产期存活率、出生时体重、儿童发育以及母亲的长期肾功能。
